The Guild of the Multiverse is the main antagonistic force of Knights of the Multiverse Season 3. They are a group formed by Black Lady made up of villains from multiple worlds to get revenge on their common foe, The so-called Knights of the Multiverse.
- Black Lady: Leader and founder
- The Dazzlings
- Vlad Plasmius
- Dr. Locus
- Genmu: recreated using Black Lady's magic and remains of Unicronian technology
- Sigma: recreated using Black Lady's magic and remains of Unicronian technology